You have set up an environment which requires proxy settings to connect to the Internet, as described in Configuring a proxy for Qlik License Service communication in Qlik Sense Enterprise on Windows. After a version upgrade you get the error message "No access path" when you open the hub.
After the upgrade, the proxy settings in the services.conf file are reset to default values.
Edit the configuration file by adding back the settings they had before the upgrade.
Path: C:\Program Files\Qlik\Sense\ServiceDispatcher\services.conf
This has to be done on every node in the cluster, followed by a restart of the Qlik Sense Service Dispatcher.